<Back to resources

<Back to publications


Published articles: The design of animal studies


Balls M, Blaauboer B, Brusick D, Frazier J et al 1990 a. Report and recommendations of the CAAT/ERGATT workshop on the validation of toxicity test procedures. Alternatives to Laboratory Animals 18: 313-337. Link


Balls M, Botham P, Cordier A, Fumero S et al 1990 b. Report and recommendations of an international workshop on promotion of the regulatory acceptance of validated non-animal toxicity test procedures. Alternatives to Laboratory Animals 18: 339-344.Link


Chapman, K., Sewell, F., Allais, L., Delongeas, J.-L., Donald, E., Festag, M., Kervyn, S., Ockert, D., Nogues, V., Palmer, H. et al. (2013). A global pharmaceutical company initiative: An evidence-based approach to define the upper limit of body weight loss in short term toxicity studies. Regulatory Toxicology and Pharmacology, 67 (1), 27-38.Link


Everds, N. E., Snyder, P. W., Bailey, K. L., Bolon, B., Creasy, D. M., Foley, G. L., Rosol, T. J. & Sellers, T. (2013). Interpreting stress responses during routine toxicity studies a review of the biology, impact, and assessment. Toxicologic Pathology, 41 (4), 560–614.Link


Everitt, J. I. (2015). The Future of Preclinical Animal Models in Pharmaceutical Discovery and Development A Need to Bring In Cerebro to the In Vivo Discussions. Toxicologic Pathology. Link


Festing, M. (2010). The design of animal experiments.  In  R.  Hubrecht  &  J.  Kirkwell (Eds.), The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals: Eighth Edition (p. 23-36).Link


Festing, M. & Altman, D. (2002). Guidelines for the design and statistical analysis of experiments using laboratory animals. ILAR journal, 43 (4), 244–258.Link


Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M. & Altman, D. G. (2010). Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biology, 8 (6), e1000412.Link


Kilkenny, C., Parsons, N., Kadyszewski, E., Festing, M. F., Cuthill, I. C.,  Fry,  D.,  Hutton, J. & Altman, D. G. (2009). Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One, 4 (11), e7824.Link


Mitchell, C. B. T. S. R., A.Z. McMahon. (2010). Sensitivity of two noninvasive blood pressure measurement techniques compared to telemetry in cynomolgus monkeys and beagle dogs. Journal of Pharmacological and Toxicological Methods, 62, 64-63.Link


Shaw, R., Festing, M., Peers, I. & Furlong, L. (2002). Use of factorial designs to optimize animal experiments and reduce animal use.  ILAR Journal, 43 (4), 223–232.Link


Wolfer, D. P., Litvin, O., Morf, S., Nitsch, R. M., Lipp, H.-P. & Würbel, H. (2004). Laboratory animal welfare:  cage  enrichment  and  mouse  behaviour.  Nature,  432 (7019), 821–822.Link


Würbel, H. (2000). Behaviour and the standardization fallacy. Nature Genetics, 26 (3), 263–263.Link


Würbel, H. & Garner, J. P. (2007). Refinement of rodent research through environmental enrichment and systematic randomization. NC3Rs, 9, 1-9.Link