<Back to resources

<Back to publications

 

Published articles: Toxicology and safety assessment using dogs

 

Box, R. & Spielmann, H. (2005). Use of the dog as non-rodent test species in the safety testing schedule associated with the registration of crop and plant protection products (pesticides): Present status. Archives of Toxicology, 79 (11), 615-626.Link

 

Chapman, K., Sewell, F., Allais, L., Delongeas, J.-L., Donald, E., Festag, M., Kervyn, S., Ockert, D., Nogues, V., Palmer, H. et al. (2013). A global pharmaceutical company initiative: An evidence-based approach to define the upper limit of body weight loss in short term toxicity studies. Regulatory Toxicology and Pharmacology, 67 (1), 27-38.Link

 

Chui, R. W., Fosdick, A., Conner, R., Jiang, J., Bruenner, B. A. & Vargas, H. M. (2009). Assessment of two external telemetry systems (Physiojacket and JET) in beagle dogs with telemetry implants. Journal of Pharmacological and Toxicological Methods, 60 (1), 58–68.Link

 

Hanton, G. & Rabemampianina, Y. (2006). The electrocardiogram of the beagle dog: reference values and effect of sex, genetic strain, body position and heart rate. Laboratory Animals, 40 (2), 123-136.Link

 

Keenan, C. M., & Vidal, J. D. (2006). Standard morphologic evaluation of the heart in the laboratory dog and monkey. Toxicologic Pathology, 34(1), 67-74.Link

 

Moscardo, E., Fasdelli, N., Giarola, A., Tontodonati, M. & Dorigatti, R. (2009). An optimised neurobehavioural observation battery integrated with the assessment of cardiovascular function in the beagle dog. Journal of Pharmacological and Toxicological Methods, 60 (2), 198-209.Link

 

Olson, H., Betton, G., Robinson, D., Thomas, K., Monro, A., Kolaja, G., Lilly, P., Sanders, J., Sipes, G., Bracken, W. et al. (2000). Concordance of the toxicity of pharmaceuticals in humans and in animals. Regulatory Toxicology and Pharmacology, 32 (1), 56-67. Link

 

Pellegatti, M. (2013). Dogs and monkeys in preclinical drug development: The challenge of reducing and replacing. Expert Opinion on Drug Metabolism and Toxicology, 9 (9), 1171-1180.Link

 

Phillips, B., Smith, D., Combes, R., G. Descotes, S. J., Hack, R., Kemkowski, J., Krauser, K., Pfister, R., Rabemampianina, Y., Sparrow, S., Stephan-Gueldner, M. & von Landenberg, F.  (2004).  An approach to minimise dog use in regulatory toxicology:  Production of a best practice guide to study design.   ALTA33 (Supplement 1), 447-451.Link

 

Robinson, S., Chapman, K., Hudson,  S.,  S, S.,  Spencer-Briggs,  D.,  Danks,  A.,  Hill, R., Everett, D., Mulier, B., Old, S. & Bruce, C. (2009). Guidance on dose level selection for regulatory general toxicology studies for pharmaceuticals. London, UK: NC3Rs/LASA.Link

 

Robinson, S., Delongeas, J.-L., Donald, E., Dreher, D., Festag, M., Kervyn, S., Lampo, A., Nahas, K., Nogues, V., Ockert, D. et al. (2008). A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development. Regulatory Toxicology and Pharmacology, 50 (3), 345-352. Link

 

Smith, D., Broadhead, C., Descotes, G., Fosse, R., Hack, R., Krauser, K., Phillips, B., Rabemampianina, Y., Sanders, J., Sparrow, S. et al. (2002). Preclinical safety evaluation using nonrodent species: an industry/welfare project to minimize dog use. ILAR Journal, 43 (Suppl 1), S39-S42.Link

Stephens, M. L.  (2011).  Pursuing Medawar’s challenge for full replacement.  Alternatives  to Animal Use in the Life Sciences, Montreal 2011, 23.Link

 

Tibbitts, J. (2003). Issues related to the use of canines in toxicologic pathology—issues with pharmacokinetics and metabolism. Toxicologic Pathology, 31(1 suppl), 17-24. Link

 

Valentin, J.-P. (2010). Reducing qt liability and proarrhythmic risk in drug discovery and development. British Journal of Pharmacology, 159 (1), 5-11.Link

 

Zurlo, J., Bayne, K., Cimino Brown, D., Burkholder, T., Dellarco, V., Ellis, A., Garrett, L., Hubrecht, R., Janus, E., Kinter, R., Luddy, E., Meunier, L.,  Scorpio,  D.,  Serpell, J. & Todhunter, R. (2011). Critical evaluation of the use of dogs in biomedical research and testing.  ALTEX, 4, 355.Link