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Published articles: Toxicology and safety assessment using dogs


Box, R. & Spielmann, H. (2005). Use of the dog as non-rodent test species in the safety testing schedule associated with the registration of crop and plant protection products (pesticides): Present status. Archives of Toxicology, 79 (11), 615-626.Link


Chapman, K., Sewell, F., Allais, L., Delongeas, J.-L., Donald, E., Festag, M., Kervyn, S., Ockert, D., Nogues, V., Palmer, H. et al. (2013). A global pharmaceutical company initiative: An evidence-based approach to define the upper limit of body weight loss in short term toxicity studies. Regulatory Toxicology and Pharmacology, 67 (1), 27-38.Link


Chui, R. W., Fosdick, A., Conner, R., Jiang, J., Bruenner, B. A. & Vargas, H. M. (2009). Assessment of two external telemetry systems (Physiojacket and JET) in beagle dogs with telemetry implants. Journal of Pharmacological and Toxicological Methods, 60 (1), 58–68.Link


Hanton, G. & Rabemampianina, Y. (2006). The electrocardiogram of the beagle dog: reference values and effect of sex, genetic strain, body position and heart rate. Laboratory Animals, 40 (2), 123-136.Link


Keenan, C. M., & Vidal, J. D. (2006). Standard morphologic evaluation of the heart in the laboratory dog and monkey. Toxicologic Pathology, 34(1), 67-74.Link


Moscardo, E., Fasdelli, N., Giarola, A., Tontodonati, M. & Dorigatti, R. (2009). An optimised neurobehavioural observation battery integrated with the assessment of cardiovascular function in the beagle dog. Journal of Pharmacological and Toxicological Methods, 60 (2), 198-209.Link


Olson, H., Betton, G., Robinson, D., Thomas, K., Monro, A., Kolaja, G., Lilly, P., Sanders, J., Sipes, G., Bracken, W. et al. (2000). Concordance of the toxicity of pharmaceuticals in humans and in animals. Regulatory Toxicology and Pharmacology, 32 (1), 56-67. Link


Pellegatti, M. (2013). Dogs and monkeys in preclinical drug development: The challenge of reducing and replacing. Expert Opinion on Drug Metabolism and Toxicology, 9 (9), 1171-1180.Link


Phillips, B., Smith, D., Combes, R., G. Descotes, S. J., Hack, R., Kemkowski, J., Krauser, K., Pfister, R., Rabemampianina, Y., Sparrow, S., Stephan-Gueldner, M. & von Landenberg, F.  (2004).  An approach to minimise dog use in regulatory toxicology:  Production of a best practice guide to study design.   ALTA33 (Supplement 1), 447-451.Link


Robinson, S., Chapman, K., Hudson,  S.,  S, S.,  Spencer-Briggs,  D.,  Danks,  A.,  Hill, R., Everett, D., Mulier, B., Old, S. & Bruce, C. (2009). Guidance on dose level selection for regulatory general toxicology studies for pharmaceuticals. London, UK: NC3Rs/LASA.Link


Robinson, S., Delongeas, J.-L., Donald, E., Dreher, D., Festag, M., Kervyn, S., Lampo, A., Nahas, K., Nogues, V., Ockert, D. et al. (2008). A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development. Regulatory Toxicology and Pharmacology, 50 (3), 345-352. Link


Smith, D., Broadhead, C., Descotes, G., Fosse, R., Hack, R., Krauser, K., Phillips, B., Rabemampianina, Y., Sanders, J., Sparrow, S. et al. (2002). Preclinical safety evaluation using nonrodent species: an industry/welfare project to minimize dog use. ILAR Journal, 43 (Suppl 1), S39-S42.Link

Stephens, M. L.  (2011).  Pursuing Medawar’s challenge for full replacement.  Alternatives  to Animal Use in the Life Sciences, Montreal 2011, 23.Link


Tibbitts, J. (2003). Issues related to the use of canines in toxicologic pathology—issues with pharmacokinetics and metabolism. Toxicologic Pathology, 31(1 suppl), 17-24. Link


Valentin, J.-P. (2010). Reducing qt liability and proarrhythmic risk in drug discovery and development. British Journal of Pharmacology, 159 (1), 5-11.Link


Zurlo, J., Bayne, K., Cimino Brown, D., Burkholder, T., Dellarco, V., Ellis, A., Garrett, L., Hubrecht, R., Janus, E., Kinter, R., Luddy, E., Meunier, L.,  Scorpio,  D.,  Serpell, J. & Todhunter, R. (2011). Critical evaluation of the use of dogs in biomedical research and testing.  ALTEX, 4, 355.Link